PUBLICATIONS

Mesial (a.k.a., medial) temporal lobe epilepsy (MTLE) is the most common focal epilepsy^(1,2) and, in drug-resistant cases, is treated by surgical removal of the anterior temporal lobe, which often shows neuronal loss and gliosis consistent with hippocampal sclerosis (HS)². MTLE with HS has minimal contribution from germline genetic variation³, and is associated with prior precipitating […]

Working memory (WM), the active retention of information over short periods, is a fundamental cognitive function, yet its underlying neural mechanisms remain unclear. In rodents, cue-selective "time cells" fire at specific timepoints after a WM memory cue, collectively forming sequences that encode cue-memory and elapsed time, providing a temporal code for maintaining information across time […]

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra (SN), accumulation of alpha-synuclein (a-Syn)-rich aggregates, and the development of both motor and non-motor symptoms. The absence of a cure for PD underscores the critical need for animal models that recapitulate both its molecular hallmarks and the spectrum of behavioral […]

Remembering the temporal order of events is critical for episodic memory, allowing us to link individual events into sequences. While the medial temporal lobe and prefrontal cortex are essential for this process, the underlying neural mechanisms remain poorly understood. Here we characterized the representation of order information at the level of single neurons and field […]

Controlling whether a given experience is encoded into long-term memory and thus later remembered is a crucial component of our memory system whose failure is often at the root of memory disorders. One brain area that takes part in controlling which experiences are remembered is the amygdala, but the mechanisms by which it does so […]

CONCLUSION: CBW recordings reveal that high-frequency DBS evokes region-specific vascular responses which can be modeled as substantial increases in local blood flow, establishing CBW amplitude as a potential biomarker of subcortical hemodynamics, and a potential therapeutic modality.

Ependymal cells in the adult spinal cord become activated after spinal cord injury (SCI), gaining stem/progenitor cell properties. Although growing evidence has implicated these cells as potential players in the endogenous repair process after injury, their activation to a stem-cell-like state is transient and insufficient for adequate regeneration. Moreover, the drivers of their activation state […]

Accurate brain signal recording and precise electrode placement are critical for the success of neuromodulation therapies such as deep brain stimulation (DBS). Addressing these challenges requires deep brain electrodes that provide high-quality, stable recordings while remaining compatible with high-resolution medical imaging modalities like magnetic resonance imaging (MRI). Moreover, such electrodes shall be cost-effective, easy to […]

Working memory (WM) enables the temporary maintenance and manipulation of information, supporting flexible, goal-directed behavior. While converging evidence suggests that the hippocampus contributes to WM storage, its causal role in WM remains unclear. Here, we combined simultaneous intracranial single-neuron recordings in the hippocampus and several cortical areas with focal electrical stimulation in the human hippocampus […]

CONCLUSIONS: Individualized treatment decisions are essential, with bilateral DBS providing superior long-term outcomes for both PD and ET.

Channelopathies affecting the hyperpolarization-activated cyclic nucleotide gated (HCN or h-) channel and the Kv7 voltage gated m-type potassium (m-) channel present a paradox in epilepsy research: despite experimental evidence that both over- and underexpression of these channels can be epileptogenic, channel overexpression does not appear to increase the excitatory-inhibitory (E-I) balance as caused by channel […]

Building brain foundation models to capture the underpinning neural dynamics of human behavior requires large functional neural datasets for training, which current implantable Brain-Computer Interfaces (iBCIs) cannot achieve due to the instability of rigid materials in the brain. How can we realize high-density neural recordings with wide brain region access at single-neuron resolution, while maintaining […]

CONCLUSIONS: Thus, our study shows that α5-PAM has robust and distinct EEG biomarkers in rodents, indicating that EEG could enable noninvasive monitoring of α5-PAM treatment efficacy.

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The central and peripheral nervous systems are specialized to conduct electrical currents that underlie behaviour. When this multidimensional electrical system is disrupted by degeneration, damage, or disuse, externally applied electrical currents may act to modulate neural structures and provide therapeutic benefit. The administration of electrical stimulation can exert precise and multi-faceted effects at cellular, circuit […]

In brain activity mapping with optogenetics, patterned illumination is crucial for targeted neural stimulation. However, due to optical scattering in brain tissue, light-emitting implants are needed to bring patterned illumination to deep brain regions. A promising solution is silicon neural probes with integrated nanophotonic circuits that form tailored beam patterns without lenses. Here we propose […]

Personalized brain implants have the potential to revolutionize the treatment of neurological disorders and augment cognition. Medical implants that deliver therapeutic stimulation in response to detected seizures have already been deployed for the treatment of epilepsy. These devices require low-power integrated circuits for life-long operation. This constraint impedes the integration of machine-learning driven classifiers that […]

Working memory (WM) and long-term memory (LTM) are often viewed as separate cognitive systems. Little is known about how these systems interact when forming memories. We recorded single neurons in the human medial temporal lobe while patients maintained novel items in WM and completed a subsequent recognition memory test for the same items. In the […]

Associating different aspects of experience with discrete events is critical for human memory. A potential mechanism for linking memory components is phase precession, during which neurons fire progressively earlier in time relative to theta oscillations. However, no direct link between phase precession and memory has been established. Here we recorded single-neuron activity and local field […]

OBJECTIVE: We retrospectively explored patients with drug-resistant epilepsy (DRE) who previously underwent presurgical evaluation to identify correlations between surgical outcomes and pathogenic variants in epilepsy genes.