Mission

The Neuron to Brain Lab (N2BL) is dedicated to unravelling the complexities of brain function, from cellular intricacies to electrophysiological activities. By integrating diverse fields such as medicine, psychology, neurobiology, engineering, and computational neuroscience, we aim to elucidate fundamental brain mechanisms. Our mission is underpinned by a commitment to community engagement and patient-centred research, driven by the active participation of our patients, whose contributions are vital in our shared pursuit of enhancing brain health.

Vision

Our vision is to advance our understanding of the brain’s fundamental mechanisms across cellular and systemic levels, using this knowledge to improve brain health for people worldwide.
By pioneering convergent research and utilizing advanced methodologies like electrophysiology, transcriptomics, and computational modelling, we aim to connect the dots between microscopic cellular functions and overall brain activity. Our goal is to transform neurological healthcare, making significant strides in treatments and interventions that enhance the quality of life for individuals affected by brain disorders.

The Team

About Dr. Valiante

Dr. Taufik A Valiante, MD PhD FRCS, is a Professor of Surgery at the Faculty of Medicine, University of Toronto, with a sub-specialization in Epilepsy Surgery. In addition to Epilepsy Surgery, he is also an expert in Minimally Invasive Spine Surgery, and Cranial Neurosurgery. Dr. Valiante holds a Senior Scientist appointment and is the Director of the Surgical Epilepsy Program at the Krembil Brain Institute at the Toronto Western Hospital, University Health Network. In addition to his role at Krembil Brain Institute, he is cross-appointed Professor in the Department of Electrical and Computer Engineering and the Institute of Biomedical Engineering at the University of Toronto. He also holds the Gerry and Tootsie Halbert Chair in Neural Repair and Regeneration.

Dr. Valiante’s vision is to build next generation devices to interrogate and modulate brain activity to cure a whole host of neuropsychiatric conditions. The goal is to one day have implantable devices with the most advanced technology that will address complex brain conditions. Dr. Valiante has also built ‘next generation’ laboratory spaces that are creating novel ecosystems bringing together in real-time basic science, clinical, and diverse scientific fields. Dr. Valiante’s research leverages access to the human brain through surgical treatment to enable Canadian first research that spans from single neuron biophysics to the collective behavior of the billions of neurons underlying human cognition. The research uses various techniques to interrogate cortical circuits including electrophysiology, behavior, optogenetics, and transcriptomics.

His efforts have been recognized by leaders nationally and internationally through supports to establish world-class infrastructures here in Toronto. He has notably established the Max Planck-University of Toronto Centre (MPUTC) for Neural Science and Technology; the Centre for Advancing Neurotechnological Innovation to Application (CRANIA); and the CRANIA Neuromodulation Institute (CNMI). These entities are driving the intersectionality of non-traditional scientific fields of medicine, engineering, and computational neuroscience working together to advance our knowledge and discovery potential that spans from the neuron to the whole brain. These centres of excellence are helping to train the next generation of scientists and leaders in Neuromodulation specialization (CNMI), building first of its kind neuromodulatory devices and interventions that will address complex brain diseases (CRANIA), and enable the pursuit of developing new physical tools and computation to explore the brain (MPUTC).

Dr. Valiante credits his success to the strong engagement of the Epilepsy Community through which this work would not be possible. Dr. Valiante strongly believes in the need for institutions to bring patient partners and communities to the table to help inform and drive research that meets their needs and is informed by what matters most to them. He has been involved in numerous community Boards and agencies, where he became acutely aware of the needs of the community, in particular, the lack of awareness and access to surgical services. Working closely with community partners, UHN and SickKids administration, he developed the chronic disease model that was the basis of the Provincial Epilepsy Strategy, which is a hub-and-spoke model of Epilepsy care in Ontario, predicated on the emerging principles of Chronic Disease Management and WHO’s Innovative Care for Chronic Disease. This has led to Ontario being the only place in the world with a regionalized approach to Epilepsy Care.

Our Videos and Podcasts

KBI Your Complex Brain Podcast Art

Your Complex Brain Podcast

Listen here for podcast episode titled:

Apple Podcasts

Podcast Research

Behind the Breakthrough

Listen here for podcast episode titled:

Apple Podcasts

Unlock the Secrets of Brain Diversity with Dr. Taufik Valiante

Dive into the fascinating world of neuroscientific research with Dr. Valiante’s groundbreaking study, published in PNAS.

Explore how the unique diversity of brain cells fortifies resilience and safeguards optimal brain function.

Don’t miss out on this awesome discovery: bit.ly/46Ae5KW.